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Graham McVicker edited Estimating overdispersion parameters.tex
over 9 years ago
Commit id: dbdf49f3db28ccbb17ef0ff0cea08de9e66489ab
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\subsubsection{Beta-Binomial}
We calculate the genome-wide likelihood of $\Upsilon_i$ by taking the product of likelihoods from all target region SNPs that are heterozygous in individual $i$. We again assume there is no genetic effect, so $p$ = 0.5, and we find the maximum likelihood estimate of $\Upsilon_i$
numerically. numerically:
\[
\textrm{L}\left(\Upsilon_i \left| D \right. \right) = \prod_k \Pr_{\mathrm{BB-mix}} \left( Y = y_{ik} \left| n_{ik}, p = 0.5, \Upsilon_i \right. \right) \\