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Graham McVicker edited The combined likelihood test.tex
almost 10 years ago
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The combined likelihood of both components of the model is:
\[
\textrm{L}\left(\alpha_h, \beta_h, \eta_j \left| D \right. \right) = \prod_i \left[ \Pr_{\mathrm{BNB}} \left( X = x_{ij} \left| \lambda_{hi}, \Phi_i, \eta_j \right. \right) \prod_k
\Pr_{\mathrm{BB-mix}}\left(Y_{ik} \Pr_{\mathrm{BB-mix}}\left(Y = y_{ik} \left| p_{h}, n_{ik}, \Upsilon_i \right. \right) \right]
\]
To test for an association with genotype we perform a likelhood ratio test that compares the alternative hypothesis $\alpha_h \neq \beta_h$ to the null hypothesis $\alpha_h = \beta_h$.