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Graham McVicker edited Modeling Allelic Imbalance.tex
almost 10 years ago
Commit id: 01459b34a50ade1119c0621307142ab6c7b3a970
deletions | additions
diff --git a/Modeling Allelic Imbalance.tex b/Modeling Allelic Imbalance.tex
index 5ee54e2..3b7a165 100644
--- a/Modeling Allelic Imbalance.tex
+++ b/Modeling Allelic Imbalance.tex
...
\textrm{L}\left( D_{h} \left| \alpha_h, \beta_h, \Upsilon_\bullet \right. \right) = \prod_i \prod_k \Pr_{\mathrm{BB}} \left( Y = y_{ik} \left| n_{ik}, p_h, \Upsilon_i \right. \right) \\
\]
where $y_{ik}$ is the number of allele-specific reads from the reference haplotype and $n_{ik}$ is the total number of allele-specific reads for individual $i$ at target SNP $k$. The expected fraction of allele-specific reads from the reference allele is
defined by the shared parameters $\alpha_h$ and $\beta_h$: $p_h = \frac{\alpha_h}{\alpha_h + \beta_h}$.