Specific Aims

Goals of the proposed research

Cerebral blood flow impairments are implicated in the pathogenesis of myriad neurological diseases, spanning from concussion to dementia.

dementia. Understanding how cerebral blood flow is regulated in normal conditions will permit the development of corrective therapies that can alter the trajectory of many neurological diseases. Studies consistently reveal two broad categories of blood flow impairment: 1. abnormal perfusion (hypo- or hyperperfusion), and 2. dampened vasodynamics, defined as a reduced ability of the cerebrovasculature to rapidly change resistance to blood flow in response to environmental shifts such as neural activity, blood pressure, oxygen level, etc.

class="ltx_title_subsection">Hypothesis