Michael Walker deleted Mutation_Instability_Filter_section_Mutation__.tex  almost 9 years ago

Commit id: 171300ef02f694aea2f5dc242ce38908ee1b24dc

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{Mutation Instability Filter}  \section{Mutation Instability Filter}  \subsection{Team Members}  \begin{list}{}  \item Charles Galea (Scientist & Problem Owner)  \item Yuri Feldman (Dev)  \item Savant Krishna (Dev)  \item Roslyn Lau (UX Design)  \item Michael Walker (Scientist)  \item Shiho Takagi (Dev)  \item Marguerite Evans-Galea (Scientist)  \end{list}  \subsection{The Problem}  Identifying genetic mutations responsible for familial disease is unnecessarily time-consuming, laborious and expensive. Current approaches typically provide 10-100 candidate genes, and eliminating the false positives requires difficult testing of individual corresponding proteins. Many bioinformaticians lack the technical expertise to streamline and speed up this process.  \subsection{The Solution}  Create a filter for bioinformaticians to greatly reduce the number of genes that must be tested. Several web-based applications exist to identify protein structures and assess their stability.  MIF takes the amino acid sequence generated by the mutated gene,  finds the corresponding protein structures, and accesses multiple   web-based stability-testing algorithms to identify those most likely to cause disease.  This will decimate the time and cost associated with identifying harmful genetic mutations. It will reduce the number of typically 100+ proteins that must be tested for harmful changes to a mere handful (2-3), greatly expediting research into genetic disease. As it identifies the protein structure responsible, it also indicates potential drug targets for medical treatment.         

Problems.tex  EPIview.tex  MIFmusical.md  Mutation_Instability_Filter_section_Mutation__.tex  Paper Boy.md  Gene Machine.md