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Real-space grids are a powerful alternative for the simulations of electrons systems. One of the main advantages of the approach is the flexibility and simplicity of working directly in real-space where the different field are directly discretized on a grid, this constitutes combined with competitive numerical performance and a great potential for parallelization. This properties constitute  a great advantage at the time of implementing and testing new physical models. In this article, based on our experience with the Octopus code, we discuss how the real-space approach has allowed for the recent  development of new ideas for the simulation of electronic systems. Approaches for the modelling of quantum transport, photoemission, control of quantum systems, and the exact solution of the Schroedinger equation for low dimensional systems.