Coding, the
process by which the published papers in our sample were read, reviewed, and
documented, was done by C.C.W., W.D.B., J. W., and T.E.N. Articles used were
the result of a PubMed search over the past 10 years. At the onset, 1086
...
genetic studies, and genome-wide association studies were excluded.
Meta-analyses were excluded to avoid redundancy, as we had already coded their
constituent studies individually. Studies combining original research with
meta-analysis were included so as to not exclude original research. (See Prisma Diagram).
Each Diagram).
An abstraction manual was formulated by D.H. to standardize the coding process. Each person was partnered with another so
that all of the coding process was reviewed once over. The papers were analyzed for nine specific
pieces of information: outcome, measurement device, metric, method of
aggregation, primacy of outcome, whether the outcome was a harm or side effect
of an intervention, study design, sample size, & study type. An abstraction manual When
coding sample size, all study participants were counted, including adult
patients or pediatric patients with a cancer other than ALL. The presence of
any pediatric ALL patients was formulated by D.H. considered sufficient to standardize fully include the
coding process.
study.
