Appendix 

Appendix  1:
((((acute AND lymphoblast* AND (leukem* OR leukaem*)) OR "Precursor Cell Lymphoblastic  Leukemia-Lymphoma"[Mesh]))

AND

(Infan* Leukemia-Lymphoma"[Mesh]))
AND
(Infan*  OR newborn* OR new-born* OR perinat* OR neonat* OR baby OR baby* OR babies OR toddler* OR minors OR minors*  OR boy OR boys OR boyhood OR girl* OR kid OR kids OR child* OR children* OR  schoolchild* OR (school[ti] AND child[ti]) OR adolescen* OR juvenil* OR youth* 
...
paediatric* OR peadiatric* OR prematur* OR preterm*) Filters: Clinical Trial;  Clinical Trial, Phase I; Clinical Trial, Phase II; Clinical Trial, Phase III;  Clinical Trial, Phase IV; Controlled Clinical Trial; Randomized Controlled  Trial; published in the last 10 year.