a44fc4f291524d31b6accea50e50387ef8b3a754
Methodology
We searched the process by which the published papers PubMed database for clinical
trials associated with treatments for acute lymphoblastic leukemia in our sample were read, reviewed, and
documented, was done by C.C.W., W.D.B., J. W., pediatric
patients published between 2005 and T.E.N. Articles used 2015. The full search strategy is described
in Appendix 1. Over 1000 studies were identified based on the result of a PubMed initial search
over the past 10 years. At the onset, 1086
potentially relevant papers were assembled. Covidence.org was used as a means
of screening criteria. These study abstracts (N=1086) were subsequently screened by CCW WDB,
JW, and titles to remove papers that TEN for inclusion based on the following inclusion exclusion criteria
(INSERT INFORMATION HERE RELATED TO SCREENING CRITERIA including this sentence
-Studies combining original research with meta-analysis werenot useful. Each
article required two separate ‘yes’ votes to be included in our study, and two
separate ‘no’ votes so as to
be excluded. not exclude original research.). Disputes over inclusion were resolved via
group
discussion. consensus. Initial screening resulted in 885 articles were included in our study retained for further review. A random sample ofwhich 285 were randomly
sampled and divided evenly four ways. After studies was selected
for full text screening, 182 articles coding. Additional studies were included. Animal excluded during this process
(e.g., animal studies, genome-wide association studies,follow-up studies of adult survivors of
pediatric ALL,exclusively
genetic studies, and genome-wide association studies were excluded. genetic studies). Meta-analyses were excluded to avoid
redundancy, as we had already coded their redundancy since the primary constituent studiesindividually. Studies combining original research with
meta-analysis were included so as to not exclude original research. included. The remaining
182 articles were retained for coding. (See Prisma Diagram).