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genetic studies, and genome-wide association studies were excluded.
Meta-analyses were excluded to avoid redundancy, as we had already coded their
constituent studies individually. Studies combining original research with
meta-analysis were included so as to not exclude original research. (See Prisma
Diagram).
An Diagram).
An abstraction manual was formulated by D.H. to standardize the coding process. Each person was partnered with another so
that all of the coding process was reviewed once over. The papers were analyzed for nine specific
pieces of information: outcome, measurement device,metric, method of
aggregation, primacy of outcome, whether the outcome was a harm or side effect
of an intervention, study design,sample size, & study type. type, metric, & sample size. With regards to metric, when an outcome element was implicitly specified, we considered it specified. E.g., because quantifying survival is, by definition, measuring time to event, specific metric for survival analysis outcomes was coded as time to event. For survival, remission, and relapse, measurement device was coded as “N/A” because, besides a calendar, there is no measurement device. For outcomes reported using scales (e.g., NCI-CTC), metric was coded as "value at a time point" unless otherwise specified within the body of the article. When coding sample size for studies including non-pediatric-ALL research, all study participants were counted, including adult
patients and pediatric patients with a cancer other than ALL.
Analysis:
After
Analysis:
After coding, outcomes were grouped into eight domains for analysis: 1) Survival; 2) Mortality; 3)
Remission; 4) Relapse; 5) Response to Treatment; 6) Adverse Event; 7) Cognitive
Event; 8) Other.