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Taylor Dunn edited section_Proofs_The_bacterial_density__.tex
over 8 years ago
Commit id: 4533389379ce75ac93a9bbbf1063f266fcf99d26
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diff --git a/section_Proofs_The_bacterial_density__.tex b/section_Proofs_The_bacterial_density__.tex
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--- a/section_Proofs_The_bacterial_density__.tex
+++ b/section_Proofs_The_bacterial_density__.tex
...
\dot{h}_a = \frac{\dot{H}_a}{H_{\rm tot}} = \frac{H}{H_{\rm tot}} \Gamma_a \rho_B = h \Gamma_a b m c
\end{equation}
The change in infectivity
$h_v$ $h_x$ is controlled by invasion
rate $\Gamma_v$, rates $\Gamma_v$ and $\Gamma_c$, and is limited by the fraction of uninfected cells and attached bacteria per cell $\tilde{b}_a$.
\begin{equation}
\dot{h}_v \dot{h}_x =
\frac{\dot{H_v}}{H_{\rm \frac{\dot{H_x}}{H_{\rm tot}} = \frac{H_a -
H_v}{H_{\rm H_x}{H_{\rm tot}}
\Gamma_v (\Gamma_v + \Gamma_c) \tilde{b}_a = (h_a -
h_v) \Gamma_v h_x) (\Gamma_v + \Gamma_c) \frac{b_a m}{h_a} = \left(1 -
\frac{h_v}{h_a}\right) \Gamma_v \frac{h_x}{h_a}\right) (\Gamma_v + \Gamma_c) b_a m
\end{equation}
Once infected by vacuolar bacteria, Similar equations can be derived for host cells
gain cytosolic bacteria at escape rate $\Gamma_c$, governed by the number of with vacuolar bacteria
per infected cell $\tilde{b}_v$. and host cells with cytosolic:
\begin{equation}
\dot{h}_v = \frac{\dot{H_v}}{H_{\rm tot}} = \frac{H_a - H_v}{H_{\rm tot}} \Gamma_v \tilde{b}_a = (h_a - h_v) \Gamma_v \frac{b_a m}{h_a} = \left(1 - \frac{h_v}{h_a}\right) \Gamma_v b_a m
\end{equation}
\begin{equation}
\dot{h}_c = \frac{\dot{H_c}}{H_{\rm tot}} =
\frac{H_v \frac{H_a - H_c}{H_{\rm tot}} \Gamma_c
\tilde{b}_v \tilde{b}_a =
(h_v (h_a - h_c) \Gamma_c
\frac{b_v m}{h_v} \frac{b_a m}{h_a} = \left(1 -
\frac{h_c}{h_v}\right) \frac{h_c}{h_a}\right) \Gamma_c
b_v b_a m
\end{equation}
%Once infected by vacuolar bacteria, host cells gain cytosolic bacteria at escape rate $\Gamma_c$, governed by the number of vacuolar bacteria per infected cell $\tilde{b}_v$.
%\begin{equation}
% \dot{h}_c = \frac{\dot{H_c}}{H_{\rm tot}} = \frac{H_v - H_c}{H_{\rm tot}} \Gamma_c \tilde{b}_v = (h_v - h_c) \Gamma_c \frac{b_v m}{h_v} = \left(1 - \frac{h_c}{h_v}\right) \Gamma_c b_v m
%\end{equation}
Host cell ruffles form at rate $\Gamma_r$, depending on the number of attached bacteria.
\begin{equation}
...
\subsection{Bacteria dynamic equations}
A more complicated quantity is the fraction of bacteria which are attached to host cells, which has three means of change. The first is by regular primary attachment with rate $\Gamma_a$, the second is ruffle recruitment with rate $\Gamma_b$, and the third is a loss of attached bacteria as they invade with limited invasion rate
$\Gamma_v^*$. $\Gamma_x^*$.
\begin{equation}
\begin{align}
\dot{b}_a = \frac{\dot{B_a}}{B_{\mathrm{tot}}} &= \frac{H_{\rm tot} \Gamma_a \rho_B}{B_{\mathrm{tot}}} + \frac{R \Gamma_b \rho_B}{B_{\mathrm{tot}}} - \frac{B_a
\Gamma_v^*}{B_{\mathrm{tot}}} \Gamma_x^*}{B_{\mathrm{tot}}} \\
&= \Gamma_a b c + \tilde{r} h_r
h_a \Gamma_b b c - b_a
\Gamma_v \Gamma_x \left(1 - \frac{\tilde{b}_x}{\tilde{b}_{x, \rm max}}\right)
\end{align}
\end{equation}
Bacterial internalization by SCV has two means of change: increasing by Bacteria will either internalize and remain vacuolar at rate $\Gamma_v^*$
and decreasing by or escape
early and become cytosolic at rate
$\Gamma_c$. $\Gamma_c^*$:
\begin{equation}
\dot{b}_v = \frac{\dot{B_v}}{B_{\rm tot}} = \frac{B_a}{B_{\rm tot}} \Gamma_v^*
- \frac{B_v}{B_{\rm tot}} \Gamma_c = b_a \Gamma_v \left(1 - \frac{\tilde{b}_x}{\tilde{b}_{x, \rm max}}\right)
- b_v \Gamma_c
\end{equation}
And finally the change in the fraction of cytosolic bacteria is simply the inverse of the second term in the above equation.
\begin{equation}
\dot{b}_c = \frac{\dot{B_c}}{B_{\rm tot}} =
\frac{B_v}{B_{\rm \frac{B_a}{B_{\rm tot}}
\Gamma_c \Gamma_c^* =
b_v b_a \Gamma_c
\left(1 - \frac{\tilde{b}_x}{\tilde{b}_{x, \rm max}}\right)
\end{equation}
\subsection{Ruffle dynamic equation}