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Taylor Dunn edited figures/misselwitz_2012_figs6/caption.tex
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\textbf{Fig. 8} HeLa cells were infected for the indicated times at an MOI of 250 with a mixture of reporter and helper strains. The reporter strain (\textit{gfp}-labeled) was either \textit{S.} Tm$^{\rm \Delta 4}$ or \textit{S.} Tm$^{\rm -T1}$ (motile, but
lacked lacks a functional TTSS-1 apparatus required for efficient docking and triggering of invasion), and the helper strain (\textit{rfp}-labeled) was either incapable of triggering ruffles (\textit{S.} Tm$^{\rm \Delta 4}$ or \textit{S.} Tm$^{\rm -T1}$) or capable (\textit{S.} Tm$^{\rm SopE}$).
(A-D) these panels show various combinations of reporter (green) and helper (red). Comparing panels A and B (no ruffling) to panels C and D, one can see the effects of cooperative invasion by the increased size of the yellow bars. (E,F) these panels show the sum of the green and yellow bars of panels A-D for the different reporter strains. Docking in this instance means both intracellular and extracellular.