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Taylor Dunn edited untitled.tex
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\subsection{Counts}
$H $N \equiv $ number of host cells
$B $N_I \equiv $ number of
bacteria attached or invaded $ = B_a + B_x $ infected cells
$\quad B_{\rm tot} $N_B \equiv $
total number of bacteria
inoculated $ = B_a + B_x + B_u $
$R $N_R \equiv $ number of ruffles
$H_a $N_r \equiv $ number
of host or ruffling cells
with $\geq 1$ bacteria attached ($\geq 1 $ ruffles)
$H_x $t_{\mathrm{max}} \equiv $
number of host cells with $\geq 1$ bacteria invaded total incubation time
$H_r \equiv $ number of host cells with $\geq 1$ ruffles \subsection{Fractions}
$B_{x, \rm max} \equiv $ maximum number of internalized bacteria per cell
$R_{\rm max} $m \equiv $
maximum number multiplicity of
ruffles per host cell infection (MOI) $ = \frac{N_B(t=0)}{N}$
$t_{\mathrm{max}} $c \equiv $
total invasion time confluency $ = \frac{N a}{L^2}$
\subsection{Fractions and Probabilities} $\quad a \equiv $ mean cellular area
$m $\quad L \equiv $
multiplicity side length of
infection (MOI), i.e. the ratio of starting bacteria to host cells $ = \frac{B_{\rm tot}}{H}$
$a \equiv $ fraction of host cells with attached bacteria $ = \frac{H_a}{H}$
$x \equiv $ fraction of host cells infected $ = \frac{H_x}{H}$
$b \equiv $ fraction of bacteria that have attached or invaded a host $ = \frac{B}{B_{\rm tot}} = b_a + b_x$
$r \equiv $ fraction of host cells with ruffling ($\geq$ 1 ruffle) $ = \frac{H_r}{H}$
$f \equiv $ probability of an attached bacteria causing a ruffle to form square well
$f^{\rm *} $x \equiv $
effective (limited) probability fraction of
ruffle formation host cells infected $ =
f (1 - \frac{R / H_r}{R_{\rm max }}) $ \frac{N_I}{N}$
$p $b \equiv $
probability fraction of
an attached bacteria
to invade the host (internalize) remaining (i.e. not landed on a host) $ = \frac{N_B}{N_B (0)}$
$\quad p^{\rm *} $f \equiv $
effective (limited) probability fraction of
invasion $ = p (1 - \frac{B_x / H_x}{B_{x, \rm max }}) $ attached bacteria that form ruffles
$\quad p $r \equiv $ fraction of host cells with ruffling ($\geq$ 1 ruffle)
$c $\tilde{r} \equiv $
confluency ruffles per cell $ =
\frac{H A}{L^2}$ \frac{N_R}{N}$
$\quad A $\tilde{b}_R \equiv $
mean cellular area bacteria per ruffle
$\quad
L \equiv $ side length of square well \tilde{b}_R(t=0) = 1$
\subsection*{Rates}
$\Gamma_a $\Gamma_0 \equiv $ primary attachment rate per bacterial density
$\Gamma_r $\Gamma_1 \equiv $ ruffle recruitment rate per bacterial density