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Taylor Dunn edited This_part_of_the_experiment__.tex
over 8 years ago
Commit id: 4511d95afb26cf072fee42ffd361e18f16d9b9a9
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This part of the experiment was mainly used as a way of validating the method of the plate count assay data in Fig. 8, with the added unexpected observation that internalized bacteria existed in a limited number of clusters or foci of infection (2 $\pm$ 1 foci per infected INT407 cell at ~40 MOI). This may be a consequence of cooperative invasion and ruffles acting as a common point of entry for invading bacteria. Interestingly, foci per cell remained consistent at ~400 MOI (data not shown), suggesting that \textit{S. Typhi} entry is saturable and may occur at a limited number of possible entry points (ruffles) per cell.
In terms of our model parameters, invasion efficiency is the probability of internalization multiplied by the fraction of bacteria attached to host cells.
\begin{equation}
\mathrm{IE} = p (1 - b)
\end{equation}