Taylor Dunn edited figures/misselwitz_2012_figs6/caption.tex  over 8 years ago

Commit id: 32709ea0f1fd718b23b2bc285bae7ff072c0ee7d

deletions | additions      

       

\textbf{Fig. 8} HeLa cells were infected for the indicated times at an MOI of 250 with a mixture of reporter and helper strains. The reporter strain (\textit{gfp}-labeled) was either \textit{S.} Tm$^{\rm \Delta 4}$ or \textit{S.} Tm$^{\rm -T1}$ (motile, but lacks a functional TTSS-1 apparatus required for efficient docking and triggering of invasion), and the helper strain (\textit{rfp}-labeled) was either incapable of triggering ruffles (\textit{S.} Tm$^{\rm \Delta 4}$ or \textit{S.} Tm$^{\rm -T1}$) or capable (\textit{S.} Tm$^{\rm SopE}$). (A-D) these These  panels show various combinations of reporter (green) and helper (red). Comparing panels A and B (no ruffling) to panels C and D, one can see the effects of cooperative invasion by the increased size of the yellow bars. (E,F) these These  panels show the sum of the green and yellow bars of panels A-D for the different reporter strains. Docking in this instance means both intracellular and extracellular.