Allen Brain Atlas data

Gene expression data were obtained from the Allen Brain Atlas Human Brain public database (http://human.brain-map.org). Gene expression data were based on microarray analysis of post-mortem tissue samples from 6 human donors between 18 and 68 years with no known history of neuropsychiatric or neurological conditions (see online documentation). MRIs and transformations from individual donors MR space to MNI coordinates were also obtained from the Allen Brain Atlas website. For the current investigation, expression values were averaged across donors and mapped onto areas of the Desikan-Killiany parcellation of the MNI brain as described by French and colleagues \cite{French_2015}. The current investigation focussed on the expression of ZDHHC9. In order to investigate the specificity of the link of ZDHHC9 expression and structural connectome organisation, we compared ZDHHC9 to a number of other genes: First, GAPDH was added as a control gene that is not associated with any known neurological or cognitive phenotype \cite{Nicholls_2012}. We then assessed genes that are associated with a similar mutation phenotype. For overlap with language deficits, FOXP2 was included \cite{Vargha_Khadem_2005}. FMR1 was selected as an X-linked intellectual disability gene \cite{Bourgeois_2009}. GRIN2A was included for the association with Rolandic Epilepsy \cite{McTague_2016}.