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Mailund et al. (2006) has developed a method to score the genealogies according to the case-control clusters and construct local genealogy trees.   \item Review Burkett et al. study briefly(!), what it found.   \begin{itemize}  \item Burkett et al. describe the effectiveness of the tree-based approach for disease risk rare variant identification by using multipledisease  haploid disease  models. \item They found that Mantel statistics computed on the known trees outperform the other methods that they have evaluated in their study.   \item However, we used  a limitation is the diploid disease model instead of  haploid disease model. model since the cells of a human are diploid.    \end{itemize}  \end{itemize}