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\begin{itemize}  \item Particularly useful when number of predictors exceeds the number of observations.  \item We select phenotype associated SNVs via elastic-net regularization from the 100 bootstrap samples.  \item We performed analysis withglmnet  R package glmnet \cite{Friedman_2010, \cite{Simon_2011}}  \end{itemize}  \end{itemize}  \item Tree-Based method