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\end{itemize}  \item Tree-Based method  \begin{itemize}  \item Inferred trees (Blossoc, \cite{Mailund_2006}): \citeNP{Mailund_2006}):  A fast accurate method to localize the disease-causing variants. \begin{itemize}  \item Approximates perfect phylogenies for each site, assuming infinite site model of mutation and scores according to the non-random clustering of affected individuals.  \item Rely on phased haplotype data.  \end{itemize}  \item True trees (MT-rank of the coalescent events, \cite{Burkett_2013}): \citeNP{Burkett_2013}):  Detect the association between disease trait and genealogical trees. \begin{itemize}  \item Upweight the short branches at the tip of the tree.   \item Success in localization was declared if the strongest signal was in the risk region.