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\end{itemize}   \end{itemize}    \item Paragraph to discuss how we scored localization and signal detection for each of these methods.  \begin{itemize}  \item Localization: scoring the distance of the peak signal from the risk region based on the average distance across the entire genomic region.   \item Detection: For a given simulated dataset and a given method, we used max. statistics across all the SNV as our global test statistics and determined its null distribution by permuting the case-control labels.   \end{itemize}  \end{enumerate}