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\item Blossoc: A fast accurate method to localize the disease-causing variants.  \begin{itemize}  \item Build perfect phylogenies for each site and score according to the non-random clustering of affected individuals.   \end{itemize}  \item Tree Stat: Detect the association between disease trait and genealogical trees.  \begin{itemize}  \item Upweight the short branches at the tip of the tree.   \end{itemize}  \end{enumerate}  \item Purpose of the study  \begin{itemize}