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\end{itemize}  \item Evaluate the localization results from the simulation study.  \begin{itemize}  \item Not surprisingly, informed-Mantel test, the bench mark outperformed all the other methods. methods since we cluster the case haplotypes that carry risk variants in informed-Mantel test.  However, Blossoc, CAVIARBF, C-alpha and Fisher's exact test performed comparably well in localizing the signal. \item Interestingly, performances were poor for both naive Mantel and VT tests.    \end{itemize}