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Charith Bhagya Karunarathna edited subsection_Analysis_and_Approaches_begin__.tex
about 7 years ago
Commit id: b975be998962f0d1b5bad89f82da86dae31def3a
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\item Rows were disease status of individuals, and columns corresponded to the three possible genotypes.
\end{itemize}
\item Each of the variant sites in the case-control sample is tested for an association with the disease outcome.
\item The $-log_{10}$ p value from the
above test is recorded as the association signal for each variant.
\end{itemize}
\item Single-variant tests are less powerful for rare variants than for common variants \cite{Asimit_2010}. We therefore considered three other ways to assess the association signal based on pooled-variant, joint-modelling and tree-based methods.
\end{itemize}