Charith Bhagya Karunarathna edited section_Discussion_begin_enumerate_item__.tex  about 7 years ago

Commit id: b0d9a83c279e335cc1021adba8212b3a654bdd00

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\item Even though the effects are one directional, C-alpha shows higher localization signal in the risk region than VT.  Our results for localization are consistent with the results of Burkett et al. for detection.  \item We would expect better results from the VT test than the C-alpha test since VT is for rare variants having the same direction of effect which we simulated.  \item However, variance-component tests such as C-alpha have higher power than burden tests such as VT when the proportion of non-causal risk  variants in the set of tested variants is low. \cite{thornton2015statistical} \end{itemize}  \item Evaluate the localization results from the simulation study.