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  \item The lack of power of single-variant approaches holds in fine-mapping as well as genome-wide association studies.  \item In this report, we are concerned with fine-mapping a genomic region that has been sequenced in cases and controls to identify disease-risk loci.  \item A number of methods have been developed to evaluate the disease association for both single-variant and multiple-variants in a genomic region.  \item  Besides single-variant approaches, methods,  we consider three broad classes of methods for analysingthe resulting  sequence data: pooled-variant, joint-modelling and tree-based methods.   \item Overview of 3 types of analysis methods (Besides single-variant approach)   \begin{itemize}