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\item Sequencing has potential to explain missing heritability through identification of trait associated rare variants. \cite{Eichler_2010}.  \item Rare genetic variants can play major roles in influencing complex diseases. \cite{Pritchard_2001} \cite{Schork_2009}  \item Standard methods to test for association with single genetic variants are underpowered for rare variants unless sample sizes are very large. \cite{Li_2008}  \item Overview of 3 types of analysis methods (Besides single SNV analysis) single-variant approach)  \begin{itemize}  \item Pooled-variant method combines the information across multiple variants sites within a gene. (can enrich the association signal).  \item Joint-modeling method identifies the joint effect of multiple genetic variants. This may be powerful since it uses combined information across variants. 
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\item Summary paragraph giving an overview of the different types of methods and the ideas motivating them.    \begin{enumerate}  \item Single-variant statistics approach  \begin{itemize}  \item Fisher's exact test  \begin{itemize}