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Charith Bhagya Karunarathna edited section_Discussion_begin_enumerate_item__.tex
about 7 years ago
Commit id: 9bd4b31f5422900141c369d844fba6caf23ee652
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\item The peak signal from all the other methods (Fisher's test, VT, CAVIARBF, Elastic-net, Blossoc and naive-Mantel) is close to the disease risk region.
\item Even though the effects are one directional, C-alpha shows higher localization signal in the risk region than VT.
Our results for localization are consistent with the results of Burkett et al. for detection.
\item
state ### State (after adding the plot) that variance-component tests such as C-alpha have higher power than burden tests such as VT when the proportion of non-causal variants in the set of tested variants is low. \cite{thornton2015statistical}
\item We would expect better results from the VT test than the C-alpha test since VT is for rare variants having the same direction of effect which we simulated.
\end{itemize}