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\subsubsection{Manhattan plots}  {\bf Single-variant approach:} Figure 1 demonstrates shows  the Manhattan plot of resultsof p values  from Fisher's exact test. The red vertical dash dashed  lines represent the disease risk region, and the vertical dash horizontal dashed  line corresponds to the significant threshold after Bonferroni correction. In our example dataset, Fisher's exact test does not localize the peak signal since the peak signal signal, which  is distal to the disease risk region.