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\begin{itemize}  \item A gene genealogy describes the relationship between individual genes sampled from a general population.  \item It has a potential to help identify genetic variants that contribute to a specific disease.  \item Methods have been developed to evaluate the disease association for both single-variant and multiple-variants in a genomic region.  %\item Identifying disease causal genetic variants may help contribute to the development of preventative and disease modifying therapies.  %\item To identify disease causal genetic variants, we can use Genetic association studies with case-control study design.  %\item About trees underlying the sequence data (where mutation occurs on tree).