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\end{itemize}   \item Pooled-variant method  \begin{itemize}  \item VT \cite{Price_2010}:Variants with MAF below some threshold are more likely to be functional than the variants with higher MAF.  \begin{itemize}  \item The variable threshold (VT) approach of Price et al. (Price 2010) is based on the regression of phenotypes onto the counts of variants meeting the MAF threshold.  \item Variants with MAF below some threshold are more likely to be functional than the variants with higher MAF.  \item For each possible MAF threshold, a genotype score is computed based on given collapsing theme. The chosen MAF threshold maximizes the association signal and permutation testing is used to adjust for the multiple thresholds.  \begin{itemize}  \item Based on collapsing variants into a two categories: variants with MAF below the threshold, and above the threshold.