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  \item Tree-based methods assess whether trait values co-cluster with the ancestral tree for the haplotypes (e.g., \cite{Bardel_2005}). Individuals carrying the same disease-predisposing variant are likely to inherit it from the same ancestor. Therefore, cases will tend to cluster together in the underlying genealogy. A method to detect clustering of the cases on the ancestral tree represents an alternative grouping method based on relatedness \cite{Burkett_2013}.   Mailund et al. (2006) has developed a method to score the genealogies according to the case-control clusters and construct local genealogy trees.   \item Reviewlimitation of  Burkett et al. study. study, what it found.  \begin{itemize}  \item Haploid However, a limitation is the haploid  disease model.   \end{itemize}  \end{itemize}