this is for holding javascript data
Charith Bhagya Karunarathna edited subsection_Analysis_and_Approaches_begin__.tex
over 7 years ago
Commit id: 826f4bba79bfea5ec9d7f4a4f87f35c85e1f9ff9
deletions | additions
diff --git a/subsection_Analysis_and_Approaches_begin__.tex b/subsection_Analysis_and_Approaches_begin__.tex
index ec04679..5d66c14 100644
--- a/subsection_Analysis_and_Approaches_begin__.tex
+++ b/subsection_Analysis_and_Approaches_begin__.tex
...
\begin{itemize}
\item VT \cite{Price_2010}:
\begin{itemize}
\item The variable threshold (VT) approach of \citeNP{Price_2010} is based on the regression of phenotypes onto the counts of variants
meeting the MAF threshold. whose minor allele frequencies (MAFs) are below some threshold (e.g. $5\%$) CHECK THIS.
\item Variants with MAF below some threshold are more likely to be functional than the variants with higher MAF.
\item For each possible MAF threshold, a genotype score is computed based on given collapsing theme. The chosen MAF threshold maximizes the association signal and permutation testing is used to adjust for the multiple thresholds.
\item \citeNP{Price_2010} found that the VT approach had high power to detect the association between rare variants and disease traits when effects are in one direction in their simulations.