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\begin{itemize}  \item Simulate 3000 haplotypes of 4000 equispaced SNVs in a 2-Mbp region.  \item Recombination rate $= 1 \times 10^{-8}$ per bp per generation.  \item Population effective size size,  $N_{e} = 6200$ \cite{Tenesa_2007} \item Randomly pair the 3000 haplotypes into 1500 diploid individuals.  \end{itemize}  \item Logistic regression model of disease status  \end{itemize}