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\item Sequence Data means rare variants  \item About trees underlying the sequence data (where mutation occurs on tree)  \end{itemize}  \item Brief literature review: CAN YOU OUTLINE THE POINTS YOU WANT TO MAKE IN THE LIT REVIEW? THIS PART IS A CRITICAL B/C IT SETS UP THE NEED FOR THE CURRENT STUDY. FOR EX, THE FACT THAT BURKETT HumHered2013  PAPER LOOKED AT POWER TO DETECT SIGNAL IN THE REGION RATHER THAN LOCALIZE IT SHD BE REVIEWED HERE. Mailund et al. shd be mentioned. OUr interest is in fine mapping a candidate genomic region on which we have sequencing data. Sequencing data is coming down in price and so is what we expect to be working with rather than common variation on SNP chips. With sequencing data we have common and rare variants. (Rule of thumb is (We have  2Mb is region;  approx equal to 2cM). Want to localize susceptibility variants rather than simply detect their presence in the genomic region of interest. Material in the intro of the DerkachEtAl. StatSci review paper may also be helpful.  \begin{enumerate}  \item Fisher's exact test  \begin{itemize}