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\item Overview of 3 types of analysis methods (Besides single SNV analysis)   \begin{itemize}  \item Pooling method combines the information across multiple variants sites within a gene. (can enrich the association signal).  \item Individuals carrying the same disease-predisposing variants are likely to inherit from the same ancestor. (Cases will tend to cluster together in the underlying genealogy)  \end{itemize}    \end{itemize} 
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\begin{itemize}  \item Inferred trees (Blossoc, \cite{Mailund_2006}): A fast accurate method to localize the disease-causing variants.  \begin{itemize}  \item Approximates perfect phylogenies for each site, assuming infinite  site model of mutation  and scores according to the non-random clustering of affected individuals. \item Rely on phased haplotype data.  \end{itemize}  \item True trees (MT-rank of the coalescent events, \cite{Burkett_2013}): Detect the association between disease trait and genealogical trees.  \begin{itemize}