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\item Even though the effects are one directional, C-alpha shows higher signal than VT which is consistent with the findings of Burkett et al.  \end{itemize}  \item Evaluate the localization results from the simulation study study.  \begin{itemize}  \item Informed Mantel test outperformed all the other methods. However, Blossoc, CAVIARBF, C-alpha and Fisher's exact test performed reasonably well in localizing the signal.  \item Interestingly, performances were poor for both naive Mantel and VT tests.    \end{itemize}  \item Evaluate the association signal detection from the simulation study.  \begin{itemize}  \item informed-Mantel test performed extremely well.  \item C-alpha, CAVIARBF, and Blossoc showed reasonably better performance results.  \item VT did not perform much better than Fisher's exact test which is a similar result described in Burkett et al.  \end{itemize}  \item MAIN CONCLUSIONS FROM THE ABOVE EVALUATIONS? THAT TREE_BASED STATS ARE THE WAY TO GO?   \item Limitations of the study  \begin{itemize}