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\begin{itemize}  \item Approximates perfect phylogenies for each site, assuming infinite site model of mutation and scores according to the non-random clustering of affected individuals.  \item \citeNP{Mailund_2006} have found Blossoc to be a fast and accurate method to localize {\bf common} disease-causing variants but how well does it work with rare variants?   \item Can use either phased or unphased haplotype genotype  data. (NOTE: We will assume both (NOTE THAT  IHAVE  CHANGED MY MIND AND NOW HERE. I  THINK WE SHOULD USE UNPHASED DATA TO MAKE TRY  BLOSSOC COMPARABLE TO THE OTHER METHODS SUCH AS FISHER'S, CAVIARBF, VT, C-ALPHA WHICH DON'T REQUIRE WITH BOTH  PHASED AND UNPHASED  DATA.) \end{itemize}  \item True trees (MT-rank of the coalescent events, \citeNP{Burkett_2013}): Detect the association between disease trait and genealogical trees.   \begin{itemize}