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\begin{itemize}  \item Fisher's exact test  \begin{itemize}  \item Each of the variant site in the case-control sample is tested for an association with the disease outcome outcome.  \item $ 2\times 3 $ table constructed to compare genotype frequencies at each variant site in case controls.  \begin{itemize}  \item Rows are disease status of individuals, and columns correspond to three possible genotypes.