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\item VT \cite{Price_2010}: Variants with MAF below some threshold are more likely to be functional than the variants with higher MAF.   \item For each possible MAF threshold, a genotype score is computed based on given collapsing theme. The chosen MAF threshold maximizes the association signal and permutation testing is used to adjust for the multiple thresholds.  \begin{itemize}  \item Based on collapsing variants into a two categories (Variants with MAF below the threshold, and above the threshold ). \item Suitable for effects in one direction.   \item \citeNP{Price_2010} found the VT approach had high power to detect the association between rare variants and disease trait in their simulations.  \end{itemize}