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\item High power to detect the association between rare variants and disease trait.  \end{itemize}  \item C-alpha: Test for the presence of rare variant mixture effect(No effect, increase risk, protective) across rare variants.  \begin{itemize}  \item Sensitive to risk and protective variants in the same gene.  \end{itemize}  \item CAVIARBF: Fine mapping method using marginal test statistics and LD in Bayesian framework.  \item Elastic-net: A hybrid regularization and variable selection method that linearly combines L1 and L2 of the Lasso and Ridge methods.  \begin{itemize}  \item Useful when number of predictors greater than number of observations.(p>>n)  \end{itemize}  \end{enumerate}  \item Purpose of the study  \begin{itemize}