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\item Tree-based methods assess whether trait values co-cluster with the ancestral tree for the haplotypes (e.g., \cite{Bardel_2005}).   \item Mailund et al. (2006) has developed a method to score the genealogies according to the case-control clusters and construct local ancestral trees.   \end{itemize}  \item Review Burkett et al. study briefly(!), what it found.   \begin{itemize}  \item Burkett et al. describe the effectiveness of such a tree-based approach for detection of rare, disease-risk variants in a candidate genomic region under various models of disease risk in a haploid population.  
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\item Unlike Burkett et al., who focus on {\em detection} of disease risk variants, we focus on {\em localization} of association signal in the candidate genomic region. Moreover, we use a diploid disease model instead of a haploid disease model.    \end{itemize}  \end{itemize}    \end{itemize}