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Charith Bhagya Karunarathna edited section_Methods_subsection_Data_simulation__.tex
over 7 years ago
Commit id: 01aed88274ac3d86e4dd6cfeb29fc78e2c255790
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\item We select the intercept term to ensure that the probability of sporadic disease (i.e. $P(D=1|G=\underset{^\sim}0)$) is approximately $20\%$.
\end{itemize}
\item We randomly sampled SNVs from the middle region one at a time, until the disease prevalence was between $9.5−10.5\%$ in the $1500$ individuals.
\item After assigning disease status to the 1500 individuals, we sampled 50 case
(i.e. diseased) and 50 control
(i.e. non-diseased) individuals from all affected and unaffected individuals.
\item We then extracted the data for the variable SNVs in the case-control sample to examine the patterns of disease association in subsequent analyses.