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\subsection{Linkage \subsubsection{Linkage  disequilibrium between polymorphic risk SNVs and other SNVs} Figure 1 shows the linkage disequilibrium (LD) between polymorphic risk SNVs and other polymorphic SNVs in the case-control sample. We here computed $r^2$ as the measure of LD, and observed some risk SNVs were in strong LD with SNVs that are outside the disease risk region (fig. 3b, g, h).