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Pairwise linkage disequilibrium disequilibria  (LD) between each risk SNV and the  remaining SNVs in the case-control sample. Filled blue circles represent the risk SNV being examined for pairwise LD with the remaining SNVs, marked by hollow black circles. Vertical dashed lines enclose the disease risk region. The measure of LD represented on the y-axis is the squared empirical correlation coefficient, $r^2$.