deletions | additions       diff --git a/Caramanos_2010_looked_specifically_at__.tex b/Caramanos_2010_looked_specifically_at__.tex  index 613cafc..907f92e 100644  --- a/Caramanos_2010_looked_specifically_at__.tex  +++ b/Caramanos_2010_looked_specifically_at__.tex 
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Caramanos 2010 looked specifically at repositioning in relation to SIENA, which is longitudinal analysis, but one could assume that repositioning affected the scan-rescan variability of some ROIs in our cross-sectional analysis. We are assuming that the consistency of positioning varies between sites, because we did not define a standardized positioning protocol. A big reason for this is because we want to be able to incorporate data that was previously acquired for future studies. In the scaling factor derivation, we take the average of the two volumes to calibrate, and calculate an "overall" bias. We do have some measure of positioning consistency that is reflected in the amount of variability due to "run" the site-by-run interaction term  in our ICC calculation, since variability in positioning will certainly contribute to the variability between runs. runs at particular sites.  This variance component is much smaller than the variance due to subjects/sites/subjects x site/unexplained, and the specific variance component for run is reported for each ROI in the supplemental materials. Overall, the majority of the variance is explained by subject, site, and the subjectxsite interaction than by run. the site by run term.