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Anisha Keshavan edited We_are_assuming_that_the__.tex
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We are assuming that the consistency of positioning varies between sites, because we did not define a standardized positioning protocol. A big reason for this is because we want to be able to incorporate data that was already acquired for future studies. In the scaling factor derivation, we take the average of the two volumes to calibrate, and calculate an "overall" bias, but we cannot say much about the bias due just to positioning. However, we do have
a some measure of positioning consistency that is calculated via the amount of variability due to "run" in our ICC
calculation. calculation - variability in positioning will certainly contribute to the variability between runs. This variance component is much smaller than the variance due to subjects/sites/subjects x
site/undexplained, site/unexplained, so we will \textbf{report this in a supplemental table}