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2. *  Assumption about independence of MRI-related biases and biological effect being studied (a_j is independent from D_u,j). It was shown that there is significant differences in detecting anatomical changes due to ageing and acquisition parameters ( see Streitburger 2014 "Impact of imageacquisition on voxel-based-morphometry investigations of age-related structural brain changes" for differences between 12-channel and 32-channel RF coil in MPRAGE and for differences caused by varying resolution).