deletions | additions       diff --git a/sectionFuture_Direct.tex b/sectionFuture_Direct.tex  index d3468ca..f4aa8d7 100644  --- a/sectionFuture_Direct.tex  +++ b/sectionFuture_Direct.tex 
...
\section{Future Directions}  The cohort that will be studied for this proposal returns every year to get an MRI scan and to be evaluated by clinicians. In the future, a longitudinal study that examines the functional metrics extracted from this proposal would help us understand if functional imaging changes across time correlate with disease progression. Compared to a cross-sectional study, longitudinal studies require larger sample sizes because longitudinal effect sizes tend to be smaller. To overcome this, we could only look at the patients whose disease progressed the most versus an age and gender matched set of patients who whose  symptoms did not change. If we observe similar patterns in the resting-state fMRI motor network of MS patients longitudinally and cross-sectionally, then these rsFMRI metrics could be used as biomarkers for clinical trials on MS drugs. In particular, a drug that targets the posteriomedial cortex and its functional connectivity to the motor network could potentially improve the ability of a subject to adapt to damage from multiple sclerosis. \bibliographystyle{plain}