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\subsubsection{Central Motor Conduction Time and Resting State fMRI}  A seed-voxel analysis will be run with connectivity maps based on the left and right precentral gyrus seeds in the hand area. Connectivity maps will be z-scored voxel-wise against created by calculating  the maps of correlation coefficient between  the healthy controls. seed region and each voxel, and then fisher-z-transformed.  A voxel-wise OLS regression will be run on the connectivity maps to predict CMCT, EDSS, and NHPT. Next cross-validation and permutation testing will be implemented to avoid overfitting the data. \subsection{Expected Results and Significance}