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My preliminary research has shown that increased functional connectivity between nodes in the default mode network and the motor strip is correlated with increased upper motor disability. Funcitonal connectivity combined with T2 lesion load explains 40\% of the variance in the nine hole peg test (a measure of upper motor disability) score in our cohort of MS patients.  \subsection{Neurophysiology of Multiple Sclerosis}  Electrophysiological measures, such as the motor evoked potential (MEP) are used for the diagnosis of MS and as a measure of dysfunction of the corticospinal tract \cite{kallmann2006early}. Increased central motor conduction times (CMCT) are seen in MS patients, which is a result of demyelination from the disease, conduction block, or axonal destruction \cite{fuhr2001evoked}. The motor evoked potential (MEP) and visual evoked potential (VEP) have been shown to be strongly predictive of changes in MS disability a full 14 years after the initial measurements \cite{schlaeger2012prediction}, with a spearman's rank correlation of $\rho = 0.69$.Therefore, CMCT may be a better outcome metric compared to EDSS, the clinical standard.